The product L-lysine sulphate is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli K-12.
L-Lysine is an essential amino acid for all animal species. L-Lysine sulphate is widely used in the feed industry to optimise the amino acid profile of diets in order to improve animal performance.
Neither the production strain nor its recombinant DNA was detected in the final product.
Therefore, the product L-lysine sulphate, feed grade, manufactured by fermentation with E. coli CGMCC 3705, does not give rise to any safety concern with regard to the genetic modification of the production strain.
Owing to potential adverse effects of the intrinsic high sulphate content in the product under application, a maximum supplementation of complete feed up to 1 % L-lysine sulphate is considered safe for all animal species and categories. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that the use in animal feed of L-lysine sulphate produced by E. coli CGMCC 3705 does not pose a risk to the consumer or the environment. L-Lysine sulphate is not considered a skin or eye irritant or a skin sensitiser.
The L-lysine sulphate under assessment is regarded as an efficacious source of the amino acid L-lysine for all animal species.
For supplemental L-lysine sulphate to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
Difference between L-Lysine Sulphate & L-Lysine HCL
The present investigations revealed that L-lysine sulfate may be a better option as a source of supplemental lysine for broilers. Dietary supplementation of L-lysine sulfate may result in higher intake of available phosphorus, total lysine, and other amino acids and may enhance nutrient metabolizability. Increased utilization efficiency of dietary protein and higher body protein accretion were observed when L-lysine sulfate was supplemented in diet and as a consequence live weight gain and feed conversion efficiency may also be improved with L-lysine sulfate. The study finally concluded that the retained bacterial cell mass may exert a value addition effect to L-lysine sulfate and makes it a superior source of supplemental lysine for broiler chickens.